The University of Sunderland is to withdraw degree courses in four subjects.
History, politics, modern languages and public health are all set to be dropped.
This follows curriculum changes to make the institution "career-focussed" and "professions facing", which have been approved by its board of governors, who aim for subjects and programmes to be "educationally and financially sustainable".
At the start of this academic year, no students joined modern foreign languages programmes, either at undergraduate or postgraduate level. In history, 14 undergraduate students were enrolled and no postgraduate students; and there were 15 undergraduate students recruited to a combined politics and history degree.
Chair of the board of governors, John Mowbray, said:
The governors also agreed that undergraduate degrees in public health would be withdrawn "because of the relevance of the course, particularly in relation to the workforce needs of regional NHS partners". There were 17 undergraduate students recruited this academic year.
All post-graduate taught degrees across the University will now be expected to have a minimum number of 15 students.
It is anticipated that 34 academic staff will be affected by these changes.
In a message to staff and students, Sir David Bell, the University’s Vice-Chancellor and Chief Executive, said: