Beamish Museum is among more than 1,300 arts venues and organisations to receive up to £1 million each from the Culture Recovery Fund.
The County Durham living history museum will be given £970,000 to support it through winter from the Government's £1.6 billion pot.
In September, Beamish Museum, which employs more than 400 staff, announced that 59 jobs were at risk of redundancy, due to the ''devastating effects'' of Covid-19.
In a statement Beamish Museum said:
Our people mean so much to us and we will seek to retain as many of the 59 roles as possible as we work through this difficult period.
Culture Secretary Oliver Dowden said the cash would ''protect these special places'' which ''form the soul of our nation''.
The funding will help performances to restart, assist venues to plan for reopening, protect jobs and create freelance opportunities, the Department for Digital, Culture, Media and Sport (DCMS) said.
Today's recipients are venues and organisations who applied for less than £1 million, with future releases of up to £3 million going to larger organisations in the future, it added.
Mr Dowden said: "This funding is a vital boost for the theatres, music venues, museums and cultural organisations that form the soul of our nation.
"It will protect these special places, save jobs and help the culture sector's recovery.
"These places and projects are cultural beacons the length and breadth of the country - from the Beamish museum in County Durham to the Birmingham Royal Ballet and the Bristol Old Vic."
The announcement comes after Rishi Sunak was accused of an "incredibly insulting" attitude towards the arts by frustrated workers currently unable to earn an income.
The Chancellor was criticised last week when, during an interview about the effect of the pandemic on people working in the arts, he spoke about the need to "adapt" and suggested there would be "fresh and new opportunities" available for those who could not do their old jobs.
But Mr Sunak has denied he was suggesting people in the struggling creative industries should retrain and find other jobs after coronavirus left them unable to work.
According to Arts Council England, the arts and culture industry contributes more than £10 billion a year to the UK economy, with £3 spent on food, drink, accommodation and travel for every £1 spent on theatre tickets.
Sarah Maxfield, Area Director North, Arts Council England said: “The pandemic has had a massive impact on the whole range of organisations working in the North’s cultural sector - theatres, music venues, festivals, museums and the companies who support them with technical sound, light and staging services.
"The cultural sector makes a huge contribution to The North’s economy, quality of life and communities. Today we are announcing much needed investment and support from the Government’s Culture Recovery Fund to a group of organisations across the North - with more announcements in the coming weeks - providing an essential lifeline so the cultural sector can survive and come back strongly in the future.”
Full List of Successful Applicants from across North East
Amber Film & Photography Collective
Cobalt TOO CIC
D6 Culture Ltd
Generator North East
Liberdade community development trust
Mandylights UK Ltd
MBC Arts Wellbeing
Mi Viejo Fruta Ltd
North East Theatre Trust Ltd
Northern Stage (Theatrical Productions) Ltd
Pink Lane Jazz Coop Ltd
Pop Recs Ltd
Seven Stories, The National Centre for Children's Books
Shindig Events Ltd
SQDL t/a Boiler Shop
Surface Area Dance Theatre CIC
The Crack Ltd
The Creative Seed CIC
The Extreme Stunt Show Ltd
Tony Hopkins Entertainments Ltd
Tyne & Wear Archives & Museums
Tyne Theatre and Opera House Limited
Durham & Darlington Music Education Hub
Durham County Council
National Youth Choirs of Great Britain
Regeneration NE CIC
The Witham Hall Ltd
APL Event Ltd
C&D Circus Productions Limited
Hexham Book Festival
Queen's Hall Arts
The Alnwick Garden
The Maltings Berwick Trust Limited
Beck & Harper Limited
Cleveland Ironstone Mining Museum
Festival of Thrift
Hartlepool Borough Council
Heugh Battery Museum
Middlesbrough Town Hall
Stockton Arts Centre Ltd
Tees Music Alliance
Tees Valley Arts
The Auxiliary Project Space
The Forum Music Studios