Three people are being held in relation to drug related deaths in Newcastle over the bank holiday weekend.
Two men aged 35 and 27 and a 33-year-old woman remain in Police custody.
Eleven people were initially arrested in the Newcastle area. Six have been released under investigation and a 14-year-old boy and 25-year old woman have been released with no further action.
It's after the death of three men over May bank holiday weekend, which are thought to be related to the drug 'Spice'.
A fourth man was admitted to hospital after taking the same substance but has since discharged himself.
Northumbria Police say they are undertaking "a thorough investigation into recent drug supply".
Superintendent Barrie Joisce, of Northumbria Police, said: “Through our role, unfortunately we often see the devastating and sometimes fatal effects drugs misuse can have on some of the most vulnerable members of society, their families and the wider community as a whole.
“Thankfully, through the hard work of our officers, we have now made eleven arrests in relation to this investigation and taken a haul of drugs off the streets.
There may be others who have taken or purchased Spice in recent days and we continue to be concerned for their wellbeing. If anyone has taken Spice then they should seek medical attention at the earliest opportunity.
“We will continue to do all we can to keep our communities safe and ensure those who look to exploit others are ultimately brought to justice.”
Ten of those in custody have been arrested on suspicion of drug offences and one man has been arrested on suspicion of manslaughter.
Anyone who suspects criminality or drug supply in their area is asked to call police on 101.Alternatively, you can contact independent charity Crimestoppers anonymously on 0800 555 111.