The A1(M) was closed after "multiple incidents" in County Durham.
Two HGVs overturned and a collision resulted in another lorry crashing through the central reservation onto the opposite carriageway, Highways England said.
The road was closed between junction 60 (Bradbury interchange) and junction 59 (Coatham Munderville) but has now reopened.
Road users have been warned to take care due to strong winds.
Durham Police said there were no injuries.
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