The US government has paid nearly £45,000 for airtime across seven Pakistani television channels to show adverts which denounce an anti-Islamic film produced in America, NBC News reports.
The ads, featuring President Obama and Hillary Clinton, Secretary of State, are aimed at quelling violent protests across the middle east sparked by the provocative film.
Mr Obama is seen to say: "Since our founding, the United States has been a nation that respects all faiths. We reject all efforts to denigrate religious beliefs of others."
Secretary Clinton says: "The United States has absolutely nothing to do with this video. We absolutely reject its contents."
A Pakistani minister offered $100,000 (£61,600) on Saturday for the death of an online filmmaker.
US Embassies across the Muslim world have come under attack and a US school in Tunisia set on fire in protests against the anti-Islam film.
Protests against the anti-Islam film continue to spread with the US embassy in Yemen stormed, while protests continue in Egypt and Iraq.