They have developed a patch that is made up of rows of tiny spikes moulded in sugar. When the patch is pressed to skin, the spikes dissolve carrying the dried vaccine into the body.
The researchers at King's College in London say the technique may one day be used in poor countries where the costs of refrigerating vaccines in prohibitive.
The patches also eliminate the risks of infecting people with contaminated needles and are pain-free.
Dr Linda Klavinskis of King’s College London, said: "This new technique represents a huge leap forward in overcoming the challenges of delivering a vaccination programme for diseases such as HIV and malaria."