Financial Secretary to the Treasury Greg Clark said the people in the regions are best placed to solve any "obstacles" that stand in the way of jobs.
Highlighting a lack of skills, and infrastructure, he said "the people who can best do something about it, are the people in those towns".
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The Prime Minister appeared to say on Sunday there is no scope to renegotiate the backstop and Withdrawal Agreement.
A medical bag containing drugs was taken from staff in Edinburgh on Saturday night.
For most it will be a little colder than on Saturday, especially in the south and the brisk easterly winds will give a marked wind chill.