The biggest shake up of the National Health Service in England, since its formation more than 60 years ago, comes into effect on Monday.
GPs will run local health services, leading new teams known as Clinical Commissioning Groups, and they will be supported by health professionals such as local hospital doctors and nurses.
The teams will decide on which health issues are a priority in their area, and where to send patients for treatment in NHS or private facilities.
They will control around 60% of the NHS budget in England but will not be in charge of major services like complex surgery and rare cancers.
But as our Political Correspondent Libby Wiener reports, ITV News has learned that only half the new groups are fully ready for Monday's reforms.
On April 1, the NHS in England will undergo the biggest reform in its history. Here's how will it affect you, and the way the NHS is run.
It seems fears over just how much competition will be injected into the NHS are still very much alive.
GPs and Labour MPs have warned that NHS reforms due to take effect in the coming weeks will lead to a free-for-all for private providers.