Former Everton striker Ayegbeni Yakubu showed his finishing prowess as Reading progressed to the last eight of the FA Cup at the expense of a Derby County side reduced to 10 men for 50 minutes.
Derby looked the better side until their full-back Stephen Warnock was sent off for a second yellow card in the 39th minute.
Hal Robson-Kanu's goal was cancelled out by Darren Bent but Yakubu, signed as a free agent during the January transfer window, netted the winner.
Olivier Giroud struck twice as FA Cup holders Arsenal beat Boro at the Emirates Stadium to book their place in the quarter-finals
League One Bradford claimed another Premier League scalp to book their place in the FA Cup quarter-finals for the first time in 39 years
Tim Sherwood saw his new Villa side edge into the FA Cup quarter finals with a 2-1 win over the Foxes at Villa Park