Business Secretary Vince Cable, Treasury Secretary Danny Alexander, former leader Charles Kennedy and Simon Hughes all fell, while at one point it looked like Nick Clegg himself would be toppled.
In all, it was a terrible night for the Liberal Democrats.
ITV News Political Correspondent Emily Morgan reports:
It was one of the last big Cabinet jobs to be announced but the Prime Minister has chosen to stick with Jeremy Hunt as Health Secretary.
Prime Minister David Cameron has today continued to put together his new cabinet. Here is what the new-look cabinet looks like so far.
David Cameron was unsurprisingly in a great mood as he spoke to journalists before addressing his 331 Conservative MPs today.