Nine Fifa officials - including two current vice-presidents - and five sports marketing executives have been indicted for corruption, the US Justice Department has said.
The defendants - including vice-president Jefferey Webb and former vice-president Jack Warner - have been indicted for racketeering, wire fraud and money laundering in connection with an alleged "24-year scheme to enrich themselves through the corruption of international soccer".
Charles "Chuck" Blazer, the ex-Fifa executive and former general secretary of Concacaf, is among four other officials and two "corporate defendants" to already plead guilty to various charges, the department said.
US and South American sports marketing executives are also among those indicted.
They are "alleged to have systematically paid and agreed to pay well over $150 million in bribes and kickbacks to obtain lucrative media and marketing rights to international soccer tournaments".
Chief Executive of the Irish Football Association John Delaney has admitted Fifa paid the organisation to avoid a legal case.
FIFA has said that Julio Grondona, who died last year, authorised a $10m payment that is at the heart of the bribery scandal.
Prince William outlined a "huge disconnect between the sense of fair play" and "allegations of corruption" within Fifa.