More than 85 MPs are bidding to speak in the Commons debate on legislation which could enshrine the right to die in British law, an "unprecedented" number.
At the start of the debate, Deputy Speaker Natascha Engel said the demand to speak from the backbenches meant MPs must keep remarks brief to allow as many into the debate as possible.
"I hope speakers will restrict themselves to five minutes, and that's including interventions," she said.
MPs have overwhelmingly rejected the Assisted Dying Bill, despite apparent public support.
MPs are set to vote on the right to die for the first time in 20 years today as controversial laws are subject to a landmark debate.
Described by the Archbishop of Canterbury as one of "the biggest dilemmas of our time", MPs are preparing to debate assisted dying.