John Kerry's speech on settlement in Israel was "skewed" and "obsessive," the Middle Eastern country's Prime Minister claims.
Benjamin Netanyahu slammed the speech, made on Wednesday in Washington, as "biased" against Israel.
The Israeli PM said Secretary of State Kerry's speech - which justified US opposition to further settlement building in the region - ignored the root of the conflict.
Netanyahu cited the root as being Palestinian opposition to a Jewish state within any borders.
Kerry's speech indicated the US belief that Israeli actions were threatening peace in the Middle East.
"Like the Security Council resolution, that Secretary Kerry advanced in the U.N., his speech tonight was skewed against Israel," a statement said.
"The Israeli leader said Kerry "obsessively dealt with settlements".
Downing Street said it was "not appropriate" for John Kerry to brand the Netanyahu administration as the "most right wing in history".
The Israeli prime minister said the country would stop funding for a number of UN bodies deemed as 'hostile' to Israel.