No US government has done more to protect Israel's security and ensure its future than Barack Obama's, according to John Kerry.
The US Secretary of State said its vote not to veto a UN resolution calling for an end to Israeli settlement building was in line with securing the Middle Eastern nation's future.
"We cannot properly defend and protect Israel if we allow a viable two-state solution to be destroyed before our own eyes," Kerry said.
He added that the US vote was about "preserving the two-state solution", maintaining that the country had shown "unwavering" commitment to Israel.
"Israel's future is a Jewish and democratic state, living side-by-side in peace and security with its neighbours," Kerry said.
He added: "No American administration has done more for Israel's security than Barack Obama's."
Downing Street said it was "not appropriate" for John Kerry to brand the Netanyahu administration as the "most right wing in history".
The Israeli prime minister said the country would stop funding for a number of UN bodies deemed as 'hostile' to Israel.