The Government's Brexit Bill has been given the go ahead in parliament after two days of intense debate.
The passing of the bill gives Prime Minister Theresa May permission to trigger Article 50 and start formal Brexit talks.
In total 114 MPs voted to oppose the UK's divorce with the EU but 498 supported it meaning the yes vote won by a majority of 384.
The vote had caused division within parties and in Labour's case it led to 47 of Jeremy Corbyn's MPs breaking the three-line whip in order to vote against the bill.
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A separate SNP-led wrecking amendment, which attempted to stop the Bill from progressing, was also defeated in the commons on Wednesday night by 336 votes to 100.
Residents in town which had the highest 'leave vote' in the referendum say Government's Brexit strategy "does not have enough detail".
Labour MP dodged questions over why she missed Brexit Bill vote in the Commons - by driving away from waiting reporters outside her home.
A four-month-old baby was a first-hand witness to the vote on triggering Article 50 - coming along with his MP mother.