Former Labour leader Ed Milliband described the vote on the government's Brexit bill as "a fateful moment in the country's history".
Speaking in the House of Commons on the second day of debate ahead of Wednesday evening's debate, Mr Miliband confirmed he will be honouring the country's mandate and voting for the Bill on its second reading.
"We do not want to give the sense that people having voted for Brexit because they felt ignored, are being ignored once again," said Mr Miliband.
He described it as "fanciful" that the negotiations would be tied-up in 18 months.
The Doncaster North MP warned against the country driving "into the arms of President Trump.
"I can't go along with the idea that Brexit means Trump," he added.
Residents in town which had the highest 'leave vote' in the referendum say Government's Brexit strategy "does not have enough detail".
Labour MP dodged questions over why she missed Brexit Bill vote in the Commons - by driving away from waiting reporters outside her home.
A four-month-old baby was a first-hand witness to the vote on triggering Article 50 - coming along with his MP mother.