American conclusions on Tuesday's alleged chemical attack in Syria are not based on "objective data", a Kremlin spokesman has said.
US President Donald Trump criticised Russia's support for the regime as he condemned President Bashar al-Assad's government over the attack, which left at least 86 people dead.
But Moscow said disagreements with the US over Syria are unlikely to change the nature of relations between the two countries in a major way.
The Kremlin said the attack was a "monstrous crime" and that the use of chemical weapons is "absolutely unacceptable".
Moscow has previously backed the Syrian government claim that the exposure was caused by a rebel arsenal of chemical weapons that was hit by an air strike.
The US Secretary of State says president Assad should have "no role" to continue governing after alleged gas attack on his own people.
Survivor of alleged Sarin nerve agent blast says 22 members of his family alone were killed in attack condemned as an "affront to humanity".
A father lost his twin babies, his wife, brothers and other family members in a suspect chemical attack in Syria on Tuesday.