Manchester City manager Pep Guardiola has ruled midfielder Kevin De Bruyne out of Wednesday's Manchester derby at Old Trafford.
The Belgian suffered the latest in a string of injury setbacks this season as he was forced off against Tottenham on Saturday.
"It is a muscular problem," Guardiola said.
"We will see in the next days but tomorrow he is not available."
Guardiola is relishing the prospect of taking on neighbours Manchester United with his side needing a victory to return to the Premier League summit.
"We have to win four games to retain our title," Guardiola added.
"It is not an easy place to go but it is a nice place to go. We know exactly what we have to do.
"It is a derby and all the times we play against United they are special games and players do their best."