Airline Loganair is halting its Londonderry to Manchester service from 5 January 2020, less than six months after the route was introduced.
The operator added the daily Manchester flight when it took over the City of Derry Airport's sole route to London in February.
Loganair has said its forecasts indicate low interest in the service post-New Year and it has decided to take a break on the route until 21 May 2020, with the exception of some flights at Easter.
In a statement Loganair Commercial Director Kay Ryan said:
"Our forecasts indicate that bookings will be low over the post New Year period, so we’ve taken the decision to take a break on the route from January 5 until May 21, with the exception of some flights at Easter.