The Duke and Duchess of Cambridge acknowledged the warm welcome of Dublin well-wishers as they arrived at a national centre supporting the mental health of young people in Ireland.
Kate waved to members of the public as she walked into Jigsaw, which provides vital support across a range of one-to-one, community, school and online services.
At the institution's Dublin centre, the couple will meet young people supported by the charity before joining a conversation with community campaigners, teachers, parents and coaches about the impact of Jigsaw's work within their respective communities.
At a reception in Dublin on Tuesday night, the duke joked about unwittingly "spreading" the coronavirus while meeting well-wishers during his Irish tour.
William poked fun at himself after he questioned a paramedic about whether he thought coverage of the illness was "being a little hyped up" in the media.
The duke's comments came as it emerged that he and Kate are taking advice on the coronavirus threat, but will continue meeting people as usual.
The Duke is to urge the UK and Ireland not to be "bound" by the wrongs of the past, in a speech echoing the Queen's historic address to the Irish people.
William is expected to highlight the importance of reconciliation, just as his grandmother did during her 2011 Ireland visit when she offered her sympathy to everyone who had suffered in centuries of conflict between the two nations.
The duke is expected to talk about the Troubles and describe how he remembers growing up with the violence that affected the UK and Ireland.
The Cambridges followed in the Queen's footsteps when they visited Dublin's Garden of Remembrance on Tuesday and paid tribute to those who fought and died for Irish independence from Britain.
In a keynote address in Dublin, William is expected to say: "Growing up I remember seeing the Troubles that took place, which affected so many people across the UK and Ireland.
"This explains why one of the truly profound moments for Catherine and I took place yesterday when we laid a wreath at the Garden of Remembrance.
"It was a reminder of the complexity of our shared history, and as my grandmother said during her visit in 2011, 'our islands have experienced more than their fair share of heartache and turbulence'.
"But it was also a reminder of how far we have come. It is right that we continue to remember those who suffered as a consequence of our troubled past.
And whilst many wrongs have been done, it is important that we are not bound by these."
The Queen helped put Anglo-Irish relations on a firmer footing nine years ago when she became the first British monarch to visit Ireland since it gained independence.
In a powerful address at Dublin Castle, she spoke of the painful legacy of the past and the need to remember all those whose lives had been affected.
She said the relationship had not always been straightforward, but stopped short of an apology for Britain's actions in Ireland, saying both nations could have acted differently.
Later the royal couple will visit Savannah House in County Kildare, a residential facility run by social justice charity Extern, which supports young people with a range of issues from being homeless to dealing with drug and alcohol problems.
Last year, the duke and duchess visited the organisation's Roscor Youth Village, in County Fermanagh in Northern Ireland, which each year provides 6,000 bed nights to young people experiencing challenges at home and in their careers.
William and Kate are making their first official visit to Ireland, a three-day trip which began on Tuesday and will take them from Dublin to Galway.
They will also visit County Meath, where they will tour Teagasc Research Farm to learn about its work promoting sustainable farming across Ireland.
Barbara McCann has this report: