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Two men aged 39 and 54 are to appear before Enniskillen Magistrates Court on Wednesday charged with money laundering and blackmail.
It follows a number of searches in Northern Ireland, Sussex and Lancashire earlier in the week.
A 48-year old woman has also been charged as part of the investigation and will appear in court later this month.
A 31-year-old woman who was also arrested has been released.
A fifth man was arrested in Sussex. He was questioned and later released.
The PSNI worked with colleagues in Sussex Police, Lancashire Police and the South Eastern Regional Organised Crime Unit as part of the operation.