Up to 130 jobs could be lost at Coleg Gwent, as the college tries to save £5.7 million. It will also result in most part time college and community courses going from September 2015.
They say it's a direct result of the £29.9 million funding cuts by the Welsh Government within the Further Education sector.
The college is now in a 45 day consultation period, working alongside staff and Trade Unions, to try to avoid compulsory redundancies where possible. Full time courses are not directly affected by the changes.
The college has five campuses across South Wales:
Blaenau Gwent Learning Zone
City of Newport
As well as two IT outreach centres in Monmouth and Cwmbran, along with a business training centre in Newport. It caters for 18,734 full and part time students.
A Welsh Government spokesperson has told ITV News that the cut in UK Government funding has meant "difficult decisions" for education budgets:
Meanwhile, Coleg Gwent warn that if such large cuts continue in the future all part time and adult learning lessons will be lost, with the exception of a small amount in priority areas like literacy and numeracy.