MPs have voted to reject a bill that would have allowed terminally ill adults to end their lives with medical supervision.
Welsh MPs were among those making emotional speeches inside the House of Commons, while protesters both for and against assisting dying gathered outside - and afterwards pledged to continue the debate.
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The Commons voted against giving a second reading to the Assisted Dying Bill by 330 to 118 - a majority of 212.
The proposals would have allowed doctors to help some terminally ill people end their lives.
It was the first time MPs had voted on the right to die for nearly 20 years.
Welsh MP Madeleine Moon spoke passionately about how she helped her husband Steve for five years, "as life changed to being a burden."
Montgomeryshire MP Glyn Davies spoke on the other side of the argument, expressing his concerns that people may feel they had to remove themselves from society, if given an option to find help in ending their lives.
Many medical professionals, such as Baroness Ilora Finlay, have argued that the Bill's requirement that people could be prescribed a lethal dose of drugs if they had fewer than six months to live would be impossible to accurately judge.
Outside parliament, one group of campaigners agreed - and celebrated as the Assisted Dying Bill was rejected.
Another group of campaigners countered that argument, chanting 'we want choice.'
Mick Murray, a friend of Blaenau Ffestiniog man Bob Cole - who recently travelled to the Dignitas clinic in Switzerland to end his life because it is illegal in the UK - told us his friend's "final wish was for the law to be changed."