The debate has now ended
Who is taking part?
The debate will include Carwyn Jones (Welsh Labour); Andrew R.T. Davies (Welsh Conservatives); Leanne Wood (Plaid Cymru); Kirsty Williams (Welsh Liberal Democrats); Nathan Gill (UKIP Wales) and Alice Hooker-Stroud (Wales Green Party).
The hashtag is #ITVWalesDebate.
What is the format of the debate?
The leaders will make short opening statements at the beginning of the programme and closing statements at the conclusion of the debate. They will also address questions posed by the audience.
The format will allow each leader to give an uninterrupted brief answer to each question, before the debate is opened to moderated discussion between the leaders, for about 15 minutes on each question.
The debate will address four substantial election questions with enough time allocated for a free flowing debate between the leaders.
ITV has asked the audience for their questions.
An experienced editorial panel is selecting the questions that will go through to the debate on the night. The leaders will not see the questions in advance.
The invited audience of around 200 people is broadly demographically representative of Wales and is politically balanced.
Earlier in the evening, Andrea Byrne will be live from the venue with a special edition of Wales at Six.
Then on polling day, Thursday, 5 May, there will a seven-and-a-half hour overnight results programme starting at 10.30pm plus a one-hour morning-after programme on Friday May 6 looking at the new political landscape in Wales.
Additionally, ITV Cymru Wales’ Welsh language current affairs team are producing a series of programmes under the banner Y Ras I’r Senedd for S4C.