Gareth Anscombe will start at fly-half for Wales in Saturday's Guinness Six Nations clash against England at the Principality Stadium.
Anscombe has been preferred to the more experienced Dan Biggar, with Wales head coach Warren Gatland naming a team showing just two changes from the side that beat France three weeks ago.
Dragons lock Cory Hill replaces Adam Beard as skipper Alun Wyn Jones' second-row partner, while scrum-half Gareth Davies takes over from Tomos Williams, who was not considered due to injury.
Prop Samson Lee was also unavailable because of injury. Tomas Francis starts at tighthead prop and opposes his Exeter team-mate Ben Moon, with Dillon Lewis on bench duty.
Gatland said: "We are really happy with the experience we have got in the side.
"We have been on the road for the first two weeks, and we are looking forward to being back at home and to build on those first two wins and to build on our performance.
"We've had a great two-week lead up to this game, we've looked really sharp and the squad are incredibly motivated to kick on.
"We know how important this game is for the rest of the championship.
"It's a massive challenge playing against an England team that is playing really well and with a lot of confidence, and we've got to make it difficult for them on Saturday."
Full-back Leigh Halfpenny again misses out following the concussion he suffered three months ago.
Scarlets star Halfpenny, who last played on November 10 when Wales beat Australia, trained with Wales this week but he is not involved in the 23-man squad.
Wales and England are the tournament's only two remaining unbeaten teams this season, with Saturday's encounter being billed by many as a Six Nations title eliminator.
Victory for Wales would see them make it 12 successive wins, breaking their record of 11 games undefeated that was set between 1907 and 1910.
England, though, have won the last five Six Nations encounters against Wales, including two in Cardiff.
It was confirmed on Friday the Principality Stadium roof will be open the clash - which is normally Wales' preference.
Under Six Nations rules, both teams have to agree for the roof to be closed.
Speaking before England's standpoint emerged, Wales head coach Warren Gatland said: "Whether it's open or not, it won't bother us.
"I think the weather conditions are going to be good. It will be a great atmosphere in the stadium. We haven't spoken at all as coaches or players about the roof.
"It is a bug-bear of mine that basically, in the Six Nations - not the autumn Tests or World Cups, when it is decided by us - I find it ironic that it is our stadium and we can't decide what we do with it."