A further 15 people in Wales have died in the last 24 hours after testing positive for coronavirus.
Latest figures from Public Health Wales reveal 384 people have now died.
Health officials also said 313 new cases have tested positive for Coronavirus in Wales, bringing the total number of confirmed cases to 5,610.
Although, they warn, the true number of cases is likely to be higher.
It comes as two more healthcare workers in Wales died over the Easter weekend, after contracting the virus.
Donna Campbell worked at one of Velindre's cancer centres before passing away in the University Hospital of Wales in Cardiff on Friday.
On Saturday it was confirmed that nurse Gareth Roberts had died in the Prince Charles Hospital in Merthyr Tydfil.
In the daily update from health officials, Dr Robin Howe, Incident Director for the Coronavirus (COVID-19) outbreak response at Public Health Wales, also said "Public Health Wales is working in partnership with the Welsh Government and the Welsh Blood Service to explore the use of convalescent plasma from people who have recovered from Coronavirus.
“Plasma from patients who have recovered from Coronavirus will contain antibodies that their immune systems have produced to fight the virus which can be transfused to patients whose immune systems are struggling to develop their own antibodies.“The initiative is at an early stage and we will be inviting eligible individuals by direct approach only at this stage.
Dr Robin Howe added, “Novel Coronavirus is now circulating in every part of Wales. The single most important action we can all take in fighting Coronavirus is to stay at home in order to protect the NHS, and save lives.
“We want to thank each and every person across Wales for doing their bit to help slow the spread of the virus.
“We know that staying at home can be hard especially when the weather is nice, but members of the public must adhere to social distancing rules about staying at home, and away from others, introduced by the UK and Welsh Government.
Coronavirus: Everything you need to know