Matthew Purnell, 30, from Cardiff, has two jobs, lives independently and does comedy in his spare time.
For every 1,000 babies born in the UK every year, one will have Down's syndrome.
Kate Harris, from Barry, found out her son James had Down's syndrome after giving birth.
Correspondent Rob Osborne writes about his uncle's condition and how society's perception of people with Down's Syndrome has improved.
A young filmmaker, who makes films featuring her little sister who has Down's syndrome, is appealing to track down the stolen footage.