The busy Heads Of The Valleys Road is closed in both directions from the Cefn Coed Roundabout to the Dowlais Top Roundabout after a lorry fire.
Firefighters are dampening down the lorry, which was carrying tyres.
The road will remain closed until Friday morning, whilst clean up takes place and 170 meters of road is resurfaced
The diversion is via the A470 to Pentrebach and then the A4060 to Dowlais Top and visa versa.
Part of the Heads of the Valleys Road is still closed in both directions after a serious accident involving a motorcyclist.
It happened shortly before 8pm last night between Brynmawr and Ebbw Vale.
The route is likely to be closed for the rush hour for an investigation.
An accident between two lorries has closed the Heads of the Valleys road between Hirwaun and Cefn-Coed-Y-Cymmer.
Emergency services are tackling a fuel spill and traffic is slown in the area.
One is lane closed after an accident involving two vehicles on the A465 Westbound between the Aberdulais Roundabout and the Neath Interchange.
Police are appealing for help following the death of a street lighting worker on the Heads of the Valleys road.
The 42-year-old was installing street lighting on the A465 between Cefn Coed and Baverstocks roundabout when an incident occurred yesterday afternoon. A 39-year-old man has been arrested and bailed pending further enquiries.
The electrician was taken to Prince Charles Hospital in Merthyr at 3pm and later died. South Wales Police and the Health and Safety Executive are both investigating.
South Wales Police would like to hear from anyone travelling through the area between 2pm and 3pm and witnessed work being carried out on the lighting installation prior to the arrival of the emergency services. Please call 101 with information.
A woman's died after a collision involving a van on the Heads of the Valleys Road.
The 41 year-old was walking away from a broken down vehicle with a man at around 7:15pm between Pant and Dowlais.
Her family are being supported by specially trained officers.
South Wales Police are appealing for witnesses, especially a motorist who stopped to speak to the van driver at the scene, to contact South Wales Police Roads Policing Unit via 101.
It is one of South Wales' busiest routes but is also known for its accident blackspots.
A project to upgrade the Heads of the Valleys Road (A465) was given the green light on 1999.
Today the latest stage of the £800million dualling scheme will be officially opened
The Welsh Government says section three of the A465 dualling scheme, Brynmawr to Tredegar, costing £158million, will improve safety and journey times, as well as boost the economy of the region.
It says the 7.8km section of road, joint funded by itself and the EU, has been upgraded from a three lane road to a dual carriageway to alleviate the current issues of poor visibility, congestion, lack of overtaking opportunities and accident hotspots.
Tributes have been paid to a pregnant woman who died in a crash on the Heads of the Valley road on Friday night.
20-year-old Sophie Williams and her unborn baby were killed in a two-car collision between Brynmawr and Ebbw Vale.