Ireland will arrive at Cardiff's Principality Stadium on the back of a record 57-15 mauling against England.
Carwyn Jones said that any customs deal on the border that was made between the north and south in Ireland should also apply for Wales.
The First Minister has released a statement following Irish Taoiseach Enda Kenny's decision to step down as leader of his Fine Gael party.
Carwyn Jones said Mr Kenny had been a 'good friend to Wales' and its relationship with Ireland is 'closer as a result'.
My statement on @endakennytd stepping down: https://t.co/ACYr8hRcPj
In a statement to colleagues in Dublin, Mr Kenny said he was retiring after 15 years at the helm of the party and more than six years at the head of the government.
Warren Gatland's Wales team will take on an Ireland side, who prop Adam Jones says will be "revved up" come kick-off.