A motorcyclist has died following a collision on the Westbound A465 between Gilwern and Llanfoist.
Emergency services were called to the scene at around twenty past midnight this morning, but the 53-year-old man from the Nantyglo area was pronounced dead at the scene.
Officers have arrested a 37-year-old man from the Brynmawr area and a 34-year-old woman from Gilwern on suspicion of causing death by dangerous driving.
Diversions on the road are likely to remain in place for several hours.
The A465 Heads Of The Valleys Road Westbound exit slip road is closed because of smoke blowing across the road at the A4143 (Llanfoist Interchange).
Merthyr Road is closed because of a burst water main between Llanelen Road and the B4269 Gipsy Lane.