Around 35 permanent jobs could be lost at the National Museum Wales as restructuring talks begin.
A further 160 posts will also be affected in some way under the proposals.
The Museum says the current financial climate is partly behind the proposed changes, along with a need to 'refocus its work to meet the changing expectations of its visitors'.
It said it hopes to avoid compulsory redundancies by offering redeployment and schemes such as voluntary redundancy and early retirement.
A 90-day consultation process is now underway.