More than a hundred pairs of shoes have been laid out on College Green in Bristol in a silent protest at the lack of funding for research into ME, also known as Chronic Fatigue Syndrome.
The empty shoes represent people who couldn't be at the protest because of the condition.
Millions of people across the world live with the complex neurological disease, Myalgic Encephalomyelitis or ME which makes them miss out on living full lives or even contribute to society.
The ME Association says that, while there is progress in other diseases, the condition misses out on funding for research and treatment as well as in help from the medical profession for sufferers. People of all ages are increasingly affected and the charity is calling for change and an end to what it describes as the #millionsmissing.
Here are some of the Tweets from today's protest.