A woman from Devon says she fears sending her disabled parents back to South Africa as it would "be like signing their death certificates."
Jo-Anne Blackmore is fighting for Dorothy and Gerald Smee to be allowed to stay in the UK, after their visa application was refused.
The couple, who are in their 80s, have a number of health issues and doctors here have advised them that it would be unsafe to fly.
However, the Home Office disagrees saying it would not be dangerous for them to go home.
Jo-Anne Blackmore has been caring for them at her home in Cullompton but was shocked to receive the refusal letter.
Her biggest worry is that they have no home to return to in South Africa and no support network there.
She has now begun a petition to try to prevent them from being deported.
In a statement, the Home Office has said "All applications are considered on their individual merits and in line with the immigration rules. Mr and Mrs Smee have the right to appeal against the Home Office's decision."
The family has begun the appeal process but it could be months before a final decision is made.