In 2017 bike riders accounted for 36% of all injuries and fatalities on roads in the West Country, according to road safety charity Brake.
Last year 797 cyclists and motorcyclists were either killed or seriously injured they say.
Brake are now urging West Country drivers to be more 'Bike Smart' by slowing down, taking care and looking properly at junctions.
The 'Bike Smart' campaign is all part of national Road Safety Week.
Two-thirds of bike deaths in 2017 took place on rural roads - the highest number of bike deaths on Britain's rural roads for more than five years.
Rural roads pose three times the risk of a fatal crash for both cyclists and motorcyclists, compared with urban roads.
Joshua Harris, director of campaigns at Brake, said: "Every hour, a cyclist or motorcyclist is killed or seriously injured on a British road.
"Raising awareness across the South West about the safety of those on two wheels, who face much higher risk of death and serious injury than those in cars, is absolutely vital.
"Rural roads, with their high speeds, blind bends and few cycle routes, pose particular danger to those on two wheels, with the risk of a fatal rural road bike crash now at its highest since 2010."