Flights between Cornwall and Heathrow airport have resumed for the first time in around 20 years.
Flybe will operate four flights a day from Newquay to London, replacing the existing route which currently takes passengers to Gatwick.
Business leaders and Cornwall Council say the new route will open up the county to new international visitors and create better transport links for people who live and work in the region.
Kim Conchie from Cornwall Chamber of Commerce said it's a "really important moment" for the county, which he said is now "open for business" with people from all over the world.
The new direct flight was hailed as a major boost for tourism when Transport Secretary Chris Grayling made the announcement last November.
Leader of Cornwall Council, Adam Paynter, said: "Having four direct flights a day to Europe's busiest airport provides us with fantastic links and more regular access not just to London, but also to the rest of the world."