The M5 near Burnham-on-Sea has re-opened following a crash shortly before 6am on Saturday morning (16 November).
Drivers faced delays of more than two hours on Saturday morning after the motorway was closed southbound from junction 22 to junction 23.
Highways England was forced to issue a warning to motorists after cars were seen driving through cones to escape heavy traffic.
In a tweet, the agency said "this action is ILLEGAL!" - it added motorists driving through the cones were putting "yourselves, our road workers and other road users" at risk.
The crash involved a lorry and a car - the female driver of the car was taken to hospital with life threatening head injuries. Police say she remains in a critical condition.
Avon and Somerset Police is carrying out a full investigation and appealing for anyone who might have witnessed the incident to come forward.
The northbound carriageway remains open.
Warnings were issued to fans travelling to St James Park for the Exeter City game against Cheltenham Town.
Both clubs tweeted advice to ticket holders to leave plenty of time for their journey to Exeter.
More travel updates here.