Exeter Chiefs' game against Toulouse on Sunday 20 December has been cancelled due to a Covid-19 outbreak.
The club confirmed a 'number of' Chiefs players and staff have tested positive for coronavirus.
This means the club will not be able to send a match-day squad to its Heineken Champions Cup round 2 fixture.
Exeter Chiefs played against Glasgow Warriors in round one of the tournament and therefore many of Glasgow Warriors' players are now self-isolating.
This means the Warriors' game against Lyon on Saturday 19 December has also been called off.