Gary Barlow, Chris Evans, James May and Brian Cox have set off from Lands End in a pink Rolls Royce raising money for Breast Cancer Care.
The challenge will see them driving from Land's End to John O'Groats in a bespoke pink Rolls Royce Ghost.
They want to try and raise £1 million in 24 hours.
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Yeovil Town football club has been taken over by new owner Scott Priestenall.
The award-winning actress inherits the role from Clare Foy for the third series on Netflix.
Jacques de Wit was riding his horse General on a public bridleway when the accident happened.