Flights from Cornwall to London Gatwick will end early next year.
Easyjet bought the landing slots from Exeter based Flybe, but now say there isn't enough demand to keep the service open.
It's a major blow for the airport at Newquay, but also for the county's business community who'll have to travel to the capital by train or road.
The nearest airport to London from Newquay will be Southend.
Our Cornwall correspondent Steve Hardy reports.
More top news
The Abbotsbury swan roundup takes place in Dorset once every two years. Hundreds of swans are brought in for vet checks.
Beech’s malicious, repeated and determined deceit ruined the reputations of those he accused
Harvey Proctor described the investigation as a ‘truly disgraceful chapter in the history of British policing’. But how did it unfold?