Flights from Cornwall to London Gatwick will end early next year.
Easyjet bought the landing slots from Exeter based Flybe, but now say there isn't enough demand to keep the service open.
It's a major blow for the airport at Newquay, but also for the county's business community who'll have to travel to the capital by train or road.
The nearest airport to London from Newquay will be Southend.
Our Cornwall correspondent Steve Hardy reports.
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