Stuart Lancaster has named winger Jack Nowell in his starting side to face Ireland at the Aviva Stadium on Sunday.
The Cornishman will replace Jonny May after his superb form for Exeter Chiefs.
Nowell failed to make the squad for England's first two Six Nations matches despite having played most of the tournament last year.
However after inspiring the Chiefs to a win over Harlequins last weekend, Lancaster could not overlook the winger's scintillating form.
This game could be be key in deciding the championship with England and Ireland the only two unbeaten sides.